Jun Fan, PhD

Assistant Professor

Department of Radiation Oncology, Emory University School of Medicine

Overview

  • Dr. Fan is researching the signaling basis of oncogenesis and cancer metabolism with a particular focus on how the mitochondrial localized tyrosine kinases and acetyltransferase/deacetylase regulate the mitochondria function to contribute to the tumorigenesis and disease progression.
  • His research will provide valuable insight to improving therapeutic strategy and outcome of cancer treatment by understanding the molecular basis of oncogenesis and cancer metabolism.
  • Dr. Fan's top research accomplishments include using proteomics and "targeted” lentiviral shRNA library screen based approaches to elucidate the signaling mechanisms by which post-translational modifications such tyrosine phosphorylation and lysine acetylation regulate several key components of PDC, including pyruvate dehydrogenase (PDH) and upstream PDH kinase (PDK) and phosphatase (PDP), providing a metabolic advantage in cancer cells to promote the Warburg effect and tumor growth.

Biography

Dr. Jun Fan obtained his PhD from University of Science and Technology of China in 2008 and was trained as postdoctoral fellow in Dr. Jing Chen's laboratory at the Winship Cancer Institute of Emory University before he was promoted to Instructor in 2012. Dr. Fan has extensive publications in major peer-reviewed journals such as Molecular Cell, Cancer Cell, Nature Communications, MCB and JBC. He received a Career Development Award from the Emory Head and Neck Cancer SPORE in 2012.

Dr. Fan is researching the signaling basis of oncogenesis and cancer metabolism with a particular focus on how the mitochondrial localized tyrosine kinases and acetyltransferase/deacetylase regulate the mitochondria function to contribute to the tumorigenesis and disease progression.
 
His research affects cancer diagnosis and treatment because understanding of the molecular basis of oncogenesis and cancer metabolism will provide valuable insight to improve therapeutic strategy and outcome of cancer treatment.
 
Amoung his top research accomplishments is using proteomics and "targeted” lentiviral shRNA library screen based approaches to elucidate the signaling mechanisms by which post-translational modifications such tyrosine phosphorylation and lysine acetylation regulate several key components of PDC, including pyruvate dehydrogenase (PDH) and upstream PDH kinase (PDK) and phosphatase (PDP), providing a metabolic advantage in cancer cells to promote the Warburg effect and tumor growth.

Publications