David S. Yu, MD, PhD

Jerome Landry MD Chair of Cancer Biology and Associate Professor

Department of Radiation Oncology

Director, Division of Cancer Biology

Department of Radiation Oncology


David S. Yu, MD, PhD, is a board certified radiation oncologist in the Department of Radiation Oncology at Emory University School of Medicine in Atlanta, GA. Dr. Yu practices general radiation oncology and specializes in the treatment of head and neck cancer, breast cancer, and lung cancer. He treats patients at the Winship Cancer Institute of Emory University and the Georgia Cancer Center for Excellence at Grady.

The goal of Dr. Yu's work is to translate insights gained from interactions with his patients and his research in the laboratory to innovative therapies to improve the quality of care for patients with cancer. He serves as Director of the Division of Cancer Biology in the Department of Radiation Oncology at Emory University School of Medicine.


Dr. Yu received his MD from the University of Texas at Southwestern Medical School and PhD from the University of Cambridge prior to completing residency training in Radiation Oncology at Vanderbilt University Medical Center. He graduated with honors from Stanford University with a BS in Biology.


Dr. Yu is a Georgia Cancer Coalition Distinguished Cancer Clinician and Scientist. He is currently funded by a NIH/NCI R01, a NIH/NCI K08, a DOD PRCRP Discovery Award, a PanCAN/AACR Career Development Award and a Georgia Cancer Coalition Distinguished Cancer Scholar Award. Dr. Yu has authored many publications in high impact journals, including Nature, Cell, Molecular Cell, EMBO, andPNAS. During his residency training, Dr. Yu was an American Board of Radiology Holman Research Pathway fellow. He received the American Society for Radiation Oncology (ASTRO) Resident Clinical/Basic Science Research Award and Radiologic Society of North America Roentgen Resident/Fellow Research Award.

Dr. Yu is a member of the ASTRO Radiation and Cancer Biology Committee Research Council, ASTRO Research Evaluation Committee Research Council, American Society of Clinical Oncology, American Association for Cancer Research, Radiation Research Society and RSNA, among others. He is also a member of the Winship Cancer Institute Cancer Genetics and Epigenetics Progam, Emory Graduate Program in Cancer Biology and Graduate Program in Genetics and Molecular Biology.


Dr. Yu is actively engaged in both clinical and science research, including, understanding how cells respond to replication stress and how to utilize this knowledge for improvements in cancer diagnosis and treatment.

In his laboratory at Emory, Dr. Yu is examining the role of sirtuin deacetylases, and more generally the acetylome, in orchestrating the replication stress response. He is working to identify novel components of the replication stress response, which mediate sensitivity of cancer cells to DNA damaging agents, utilizing high throughput loss of function genetic screens. His lab is also focused on understanding mechanistically how novel replication stress response proteins function using cell biological, genetic, and biochemical approaches to define the functions of these proteins. He hopes to translate insights gained from mechanistic analyses to improvements in the clinic. By exploiting defects in the replication stress response, he hopes to utilize novel replication stress response proteins as biomarkers for clinical response and outcome to specific cancer treatments and as novel therapeutic targets to personalize cancer therapy.

Yu Lab Website