Department of Radiation Oncology
Emory University School of Medicine
Georgia Research Alliance Cancer Scientist
Winship Cancer Institute
Building C, Room 3008
1365 Clifton Road NE
Atlanta, GA 30322
Congratulations to Bill Hall for his first-author publication in Oncogene on how low CHD5 expression activates the DNA damage response and predicts for poor outcome in patients with early-stage resected pancreatic cancer. Dr. Hall also received first place for his presentation of this work on Resident Research Day.
Congratulations to Hui Zhang for her first-author publication in PNAS on how SIRT2 directs the replication stress response through CDK9 deacetylation. Dr. Zhang gave an oral presentation of this work at the RRS annual meeting in New Orleans.
Dr. Yu is actively engaged in both clinical and basic science research. He is interested in understanding how cells respond to replication stress and how we can utilize this knowledge for improvements in cancer diagnosis and treatment. One interest of the lab is to understand the role of sirtuin deacetylases, and more generally the acetylome, in orchestrating the replication stress response. A second interest of the lab is to identify novel components of the replication stress response, which mediate sensitivity of cancer cells to DNA damaging agents, utilizing high throughput loss of function genetic screens.