• Localization of GFP-HMGB1 to DNA damage induced by laser micro-irradiation

  • Co-localization of novel RSR protein with RPA


David S. Yu, M.D., Ph.D.
Assistant Professor
Department of Radiation Oncology
Emory University School of Medicine
Georgia Research Alliance Cancer Scientist
Winship Cancer Institute
Building C, Room 3008
1365 Clifton Road NE
Atlanta, GA 30322

404-778-1758 (office)
404-778-5520 (fax)
404-778-2193 (lab)


Congratulations to Elaine Liu who will be enrolling in the MSTP program at the University of Michigan Medical School.

Congratulations to Lauren Colbert for her first-author publication in Cancer Research Journal on how CHD7 is a novel DNA damage response protein whose expression predicts survival outcomes in patients with resected pancreatic cancer. Lauren also received a RSNA Medical Student Research Grant and an Emory Radiation Oncology Medical Students Scholars Award to complete this work.  

Congratulations to Bill Hall for his first-author publication in Oncogene on how low CHD5 expression activates the DNA damage response and predicts for poor outcome in patients with early-stage resected pancreatic cancer. Dr. Hall also received first place for his presentation of this work on Resident Research Day.

Congratulations to Hui Zhang for her first-author publication in PNAS on how SIRT2 directs the replication stress response through CDK9 deacetylation. Dr. Zhang gave an oral presentation of this work at the RRS annual meeting in New Orleans.

Our Research

Dr. Yu is an Assistant Professor in the Department of Radiation Oncology at Emory University School of Medicine. He received his MD from the University of Texas at Southwestern Medical School and PhD from the University of Cambridge prior to completing residency training in Radiation Oncology at Vanderbilt University Medical Center. He graduated with honors from Stanford University with a BS in Biology.

Dr. Yu is actively engaged in both clinical and basic science research. He is interested in understanding how cells respond to replication stress and how we can utilize this knowledge for improvements in cancer diagnosis and treatment. One interest of the lab is to understand the role of sirtuin deacetylases, and more generally the acetylome, in orchestrating the replication stress response. A second interest of the lab is to identify novel components of the replication stress response, which mediate sensitivity of cancer cells to DNA damaging agents, utilizing high throughput loss of function genetic screens.